Keane believes that United are far superior to the rest and the likes of Chelsea, Liverpool and Arsenal don’t stand a chance.
"Even Sir Alex Ferguson said the other day the league's getting tougher. But I don't think so," Keane told The Sun.
"If United are really at it, which they will be, they'll win it comfortably. Even last year when United were slipping up, no team was strong enough to take advantage of it."
Keane said the arrival of Chelsea manager Andre Villas-Boas will not see the London based outfit get any nearer to stopping United from going on and on.
"Everybody is on about this new young manager -- but I don't think the manager will be the problem," Keane added.
"It's always the players down there, they all seem to self-destruct. They're big pals one minute and the next you hear they're all bickering with each other and players aren't happy if someone else scores."
And as for the other two hopefuls..
"Arsenal haven't really bought anybody," he said.
"They've signed a striker, Gervinho, and, while the jury's out, you always have to give a boy a chance.
"Liverpool have bought good attacking players but I think it's actually defenders that they need. I think we've seen that a little bit in pre-season.
"Don't get carried away, Liverpool are in no position to win the league, nowhere near."