The Blues are on a goal roll with Carlos Tevez scoring six in the last three matches and Emanuel Adebayor hitting four in the last two games.
It means Sir Alex Ferguson is keen for England defender Ferdinand to team up again with Nemanja Vidic for the Eastlands showdown.
Ferdinand had to limp on at Blackburn on Sunday with United having used all their subs.
The 31-year-old suffered another groin problem which has dogged him all season.
"Rio signalled to us that he was starting to tighten up a little bit," says United number two Mike Phelan.
"It was difficult after that. We had to throw him up through the middle. He couldn't contribute much to the game.
"We thought about bringing him off and playing with 10 men. We tried to do something and it didn't work.
"We need to have a look a bit more closely."
John O'Shea had to be subbed because of tiredness at Ewood Park in his first start since November. But Ryan Giggs (hamstring) is a doubt for Saturday's clash.
Meanwhile, Ferdinand has revealed the secret of Tevez' lung bursting match day displays.
The England defender said: "Carlos is an interesting character. When he was at United he saved all his energy for the games. He'd do his work in the gym - he was a professional in that sense - but everything he did was geared towards the match at the weekend.
"You could see him convserving his energy during the week. That's not the way I operate. I have to train at a high level every day."
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Source: Manchester Evening News
Source: M.E.N.