The game will be the first to be played at Anfield since the damning report on the Hillsborough tragedy was released last Wednesday, placing the blame for the disaster, in which 96 people died, on South Yorkshire Police and other services.
"It is going to be a very emotional day on Sunday and we will support them in every way we can," said Ferguson.
Yet the chants of a few United fans during Saturday's win over Wigan at Old Trafford highlighted the potential for trouble.
Ferguson added: "As a club we are totally supportive of Liverpool in the situation they are in. We understand what those families must have felt when they got that report.
"I didn't hear it (on Saturday), but others did, particularly in the directors' box. (Chief executive) David Gill was disappointed."
Some fans have argued the chant heard on Saturday - "Always the victim, never your fault" - was only sung in the immediate aftermath of Luis Suarez's racism spat with Patrice Evra.
"It is a new chant that only started after the Suarez situation," said Ferguson. "I was disappointed to hear it. It is a minority. But in society there is a minority wanting to be heard."