England striker Wayne Rooney has been left out of Manchester United's Community Shield squad because of a shoulder injury.
Ashley Young and Nani miss out for United but Robin van Persie, Nemanja Vidic and Patrice Evra should be fit after missing Rio Ferdinand's testimonial.
Wigan will be without captain Gary Caldwell but the game could provide a debut for new signing James McClean.
Thomas Rogne, is out with a back problem for the Latics, though Leon Barnett and Emmerson Boyce are expected to retain their places in Owen Coyle's side.
Manchester United: De Gea, Rafael, Vidic, Jones, Evra, Zaha, Carrick, Cleverley, Giggs, Robin van Persie, Welbeck.
Subs: Lindegaard, Evans, Anderson, Smalling, Valencia, Kagawa, Januzaj.
Wigan Athletic: Carson, Boyce, Perch, Barnett, Crainey, McCarthy, Watson, McArthur, Maloney, Holt, McClean.
Subs: Nicholls, McCann, Gomez, McManaman, Espinoza, Dicko, Fortune.