Man Utd will be seeking to strengthen their top four credentials as they welcome Leicester to Old Trafford in the Premier League.
The Reds were defeated in their previous outing on home soil when they crashed out of the Champions League at the hands of Atletico Madrid, although Cristiano Ronaldo's hat-trick against Tottenham kept Ralf Rangnick's side in the hunt for top four.
United currently trail Arsenal by four points having played a game more and they will be keen to avoid any slip-ups before they visit the Gunners in April.
Here's how the Red Devils could line up this weekend.
1. Goalkeeper & defenders
David de Gea (GK) - The Spaniard is perhaps the biggest reason that Man Utd are still in the hunt for Champions League football.
Diogo Dalot (RB) - A more attacking option than Aaron Wan-Bissaka, which will be required in a fixture such as this.
Raphael Varane (CB) - Suffered an injury scare for France last weekend, but he will be fit enough to start for United.
Harry Maguire (CB) - Jeered by sections of the England crowd on international duty and he will be keen to prove a point.
Alex Telles (LB) - The Brazilian is either hit or miss for Man Utd, with Rangnick preferring his qualities over those of Luke Shaw's.
2. Midfielders
Scott McTominay (CM) - His all-action energy is perfectly suited for Rangnick's style of football.
Fred (CM) - Has benefitted hugely from Rangnick's arrival, unlocking his creative side.
Bruno Fernandes (AM) - Fired Portugal to the World Cup with a brace against North Macedonia on international duty.
3. Forwards
Anthony Elanga (RW) - A hugely exciting prospect for Man Utd, underlining his potential with an impressive display against Atletico Madrid in the Champions League.
Cristiano Ronaldo (ST) - Netted just his second United hat-trick in his previous Old Trafford outing in the Premier League.
Jadon Sancho (LW) - Has come to life in a United shirt in recent months after a difficult adaptation period under Ole Gunnar Solksjaer.
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Source : 90min