Ferguson has targeted the six-week run of fixtures from mid-January onwards as the games that United could do with maximum points from to keep up with and eventually overtake Man City at the top of the table.
United have already taken full points from Arsenal and Liverpool recently as well as a point from Chelsea after going three down, now they sit just two points behind.
"It's going to be a massive game at Spurs" Ferguson told Inside United. "If we can survive that one, then we'll have a big chance of winning the league.
"I would take it [being two points behind City going into the game at the Etihad Stadium]. I would rather go there on level points. But if we could go there within striking distance of being top of the league, I'd take it."