Many supporters have been left mystified by Kagawa's omission, particularly given United only collected one win from their first three games.
Yet Moyes is adamant there is nothing sinister going on.
"There are quite a lot of players who have not featured yet," he said.
"But if you look at it most of them were late back from international duty after the Confederations Cup, then they were away for a friendly international and a long-haul flight, then they were away again for another international.
"If you look at the reasons why people haven't played it is more to do with them not being available for that to happen."
Neither does Moyes feel he has any need to speak with Patrice Evra about his attempt to sign both Leighton Baines and Fabio Coentrao on deadline day.
"He (Evra) knew exactly what we were doing," the Scot said.
"I just felt we needed to make sure we had good cover for Patrice.
"He has played brilliantly well but I hope we are going to have a season that is going to include 60 or 70 games.