Cristiano Ronaldo and Nani have been named in Manchester United's line-up to face their former club Sporting Libson.
John O'Shea, Darren Fletcher and keeper Tomasz Kuszczak will also play, while defender Nemanja Vidic could replace Gerard Pique after a back problem.
Brazilian forward Liedson bruised his right thigh in Sporting's league game at the weekend but is expected to play.
Keeper Vladimir Stojkovic has recovered from a hip injury but 19-year-old Rui Patricio is likely to retain his place.